Choose The Best Rapid Syphilis Test

Syphilis is a disease caused by a spirochete called Treponema pallidum (TP). If untreated, the organism moves across the body and can cause damage to many organs, making syphilis life-threatening diseases if not treated early fully. Serological response to syphilis involve the production of antibodies against various antigens, including non-specific antibodies and specific anti-TP antibody. The first response to infection is detected the production of specific anti-treponemal IgM, which can be detected within 4 to 7 days after the chancre appears and until the end of the second week of infection, anti-treponemal IgG appeared in about four weeks later. The symptoms of syphilis as the disease progresses, most patients have both IgG and IgM detected. Syphilis infection can spread through the bloodstream to all parts of the body. If untreated, syphilis can cause severe heart disease, brain damage, spinal cord damage, blindness, and death.

Syphilis is a public health problem in many persistent low-income countries that have limited capacity for testing, which has traditionally relied on non-treponemal tests are sensitive and specific treponemal tests. However, the development of new rapid treponemal tests provide opportunities to enhance syphilis screening in many settings where traditional tests are not available.

The reason you might not be able to perform the test or why the results can not be helpful include:

# The use of antibiotics before having the test.

# A blood transfusion in the weeks before a test.

# Has other conditions or diseases, like lupus, heart disease, HIV infection, or yaws.

Common Q&A of Oral Aids Test

What is the significance of the Food and Drug Administration’s (FDA) approval of the OraQuick rapid HIV test for oral fluid on March 26, 2004?
The FDA has approved the OraQuick Advance HIV1/2 Antibody Test for use with oral fluid and for use on plasma specimens. Until now, the test, manufactured by OraSure Technologies, Inc., was approved only for whole blood specimens. This is the only rapid HIV test to be approved in the US by the FDA for use with oral fluid.

What is the difference between the OraQuick Advance Rapid HIV 1/2 Antibody Test for oral fluid and the OraQuick Rapid HIV-1 Antibody Test for blood approved by the Food and Drug Administration in November 2002?
The FDA approved the new version of the test for the detection of HIV-2 antibodies and for use with additional types of specimens. Until now, the OraQuick rapid HIV antibody test required a whole blood specimen, either from a fingerstick or a tube of blood. The OraQuick Advance test can now be used with oral fluid specimens taken from the mouth, with plasma, and with whole blood. Additionally, the new version of the test can be performed in a wider range of operating temperatures (59°F to 99°F).

Is the OraQuick test a saliva test?
No. The test uses oral fluid, which is slightly different from saliva. To perform the test, the person being tested for HIV gently swabs the device completely around the outer gums, both upper and lower, one time around and inserts it into a vial containing a developer solution. After 20 minutes, the test device will indicate if HIV antibodies are present in the solution by displaying two reddish-purple lines in a small window in the device.

What does a reactive or preliminary positive result mean?
A reactive HIV test result on oral fluid is a preliminary positive and needs to be confirmed by an additional, more specific test to verify whether HIV antibodies are present.

How well does the test work?
In the clinical studies by the manufacturer, the OraQuick oral fluid test correctly identified 99.3% of people who were infected with HIV (sensitivity) and 99.8 % of people who were not infected with HIV (specificity). The Food and Drug Administration expects clinical laboratories to obtain similar results.